Name | Cooper Tripeptide1 |
Synonyms | Ghk-Cu |
Use | Copper peptides can be used in laboratory research and development processes and chemical and pharmaceutical synthesis processes. |
GHK-Cu(Copper Glycyl-histidine-tripeptide) is a compound that combines glycyl histidine lysine tripeptide (Glycyl tripeptide, GHK) with copper. it is named blue copper peptide /blue copper peptide because its aqueous solution is blue. it is a small molecule copper peptide complex naturally occurring in human plasma, urine, saliva and cerebrospinal fluid.
GHK is a tripeptide first isolated from human plasma by Pickart et al. in 1973. it is described as a regulator of growth factor and extracellular matrix of various differentiated cells. The plasma concentration of GHK is significantly related to the regeneration ability of organisms. Studies show that the plasma concentration of GHK in 20-year-old young people (200 ng/mL,ng: nanograms) is 2.5 times that of 60-year-old old people (80 ng/mL). Later, it was found that GHK and divalent copper have high affinity and can spontaneously combine with them to form complex GHK-Cu.
The functions of blue copper peptide mainly include: 1. Effectively promotes the production of collagen , increases blood vessel growth and antioxidant capacity, and stimulates the production of glucosaminoglycans, helping the skin to restore self-repair Ability; 2. Promote the growth and differentiation of epithelial cells, thereby accelerate the healing of wounds ;3. Promote the proliferation of hair follicles and increase the size of hair follicles, Promote hair growth .
References:
[1] Meng Xiangyu. Clinical observation of tripeptide -1 copper (GHK-Cu) in the treatment of androgenetic alopecia. Master's thesis of Jilin University. 2021.
[2] Zhang Fenglong. The latest research progress of GHK tripeptide. Technological innovation and application. 2018.
[3] Zhang Chuxin. Study on the effects of copper peptides and phenolic compounds on tyrosinase. Master's thesis of Liaoning Normal University. 2019.
[4] Peng Kunjian. Preparation and characterization of GHK-Cu liposomes and their effects on mouse hair growth. Medical Guide. 2013.
[5] Travis Badenhorst. Effects of GHK-Cu on MMP and TIMP Expression, Collagen and Elastin Production, and Facial Wrinkle Parameters. J Aging Sci. 2016.
[6] Loren Pickart. Regenerative and Protective Actions of the GHK-Cu Peptide in the Light of the New Gene Data. Int. J. Mol. Sci. 2018.
[7] Leyden J. Skin Care Benefits of Copper Peptide Containing Eye Creams. University of Pennsylvania. 2002.